5-Methyltetrahydrofolate is the main form of folate found in blood serum and it is the active form of folate, often referred to as active folate.

So what is active folate? What does inactive folate look like?

Inactive folate is the folate we take in from food or synthetic folate, both of which require activation by a number of reactions catalysed by specific enzymes (e.g. dehydrofolate reductase, methyltetrahydrofolate reductase), i.e. the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by MTHFR, so that it can be absorbed and used by the body.

Therefore folate, whether consumed from food or from synthetic folate, is not in an active state.

folate that needs to undergo a series of conversion processes is not active folate.

5-Methyltetrahydrofolate is the end product of a metabolic process and is active if it can be absorbed directly by the body without metabolism. 

Magnafolate 5-Methylfolate raw materials

Magnafolate 5-Methyltetrahydrofolate Ingredients