| 中文名 | 阿瑞吡坦 |
| 英文名 | Aprepitant |
| 别名 | 阿瑞吡坦 阿瑞匹坦 阿瑞匹坦(阿瑞吡坦) 阿瑞匹坦 (API) 中间体1(即阿瑞匹坦) FS-福沙吡坦中间体8 APREPITANT阿瑞吡坦 阿瑞匹坦APREPITANT 5-[2(R)-[1(R)-[3,5-二(三氟甲基)苯基]乙氧基]-3(S)-(4-氟苯基)吗啉-4-基甲基]-3,4-二氢 5-[2(R)-[1(R)-[3,5-二(三氟甲基)苯基]乙氧基]-3(S)-(4-氟苯基)吗啉-4-基甲基]-3,4-二氢-2H-1,2,4-三唑-3-酮 5-(2(R)-(1(R)-(3,5-二(三氟甲基)苯基)乙氧基)-3(S)-(4-氟苯基)吗啉-4-基甲基)-3,4-二氢-2H-1,2,4-三唑-3-酮 |
| 英文别名 | Emend CS-274 MK-0869 Aprepitant Aprepitant(MK-0869) Aprepitant (MK-0869, L-754030) 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1, 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend |
| CAS | 170729-80-3 |
| EINECS | 677-636-6 |
| 化学式 | C23H21F7N4O3 |
| 分子量 | 534.43 |
| InChI | InChI=1/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1 |
| 密度 | 1.51±0.1 g/cm3(Predicted) |
| 熔点 | 244-246°C |
| 比旋光度 | D25 +69° (c = 1.00 in methanol) |
| 溶解度 | Soluble in DMSO (>25 mg/ml) |
| 折射率 | 1.564 |
| 酸度系数 | 8.06±0.20(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 稳定性 | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| 外观 | powder |
| 颜色 | white to beige |
| 海关编号 | 2934990002 |