| 中文名 | 甲氨蝶呤 |
| 英文名 | Methotrexate |
| 别名 | 氨蝶呤 甲氨碟呤 氨甲喋呤 胺甲喋呤 甲氨蝶呤 氨甲叶酸 氨甲蝶呤 氨甲基叶酸 甲基蓝钠盐 甲氨基叶酸 胺甲喋呤水合物 (+)氨甲蝶呤 二水合氨甲嘌呤 甲氨蝶呤原料药 METHOTREXATE 甲氨蝶呤 对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸 |
| 英文别名 | Mtx Antifolan 4-Amino-1 Amethopterin Methotrexate L-Methotrexate (+)-Amethopterin Methotrexat-Ebewe Methylaminopterin Methylaminopterine L-(+)-Amethopterin Methylpteroylglutamate 4-Amino-4-Deoxy-N(Sup10 METHOTREXATEFORINJECTION Methylpteroylglutamic Acid 4-Amino-10-Methylfolic Acid 4-Amino-N10-methylfolic acid (+)-4-Amino-10-Methylfolic Acid 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID) L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI) Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI) sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate |
| CAS | 59-05-2 |
| EINECS | 200-413-8 |
| 化学式 | C20H22N8O5 |
| 分子量 | 454.45 |
| InChI | InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m1/s1 |
| InChIKey | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| 密度 | 1.4080 (rough estimate) |
| 熔点 | 195°C |
| 沸点 | 561.26°C (rough estimate) |
| 比旋光度 | +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis) |
| 闪点 | 11℃ |
| 水溶性 | Insoluble.<0.1 g/100 mL at 19 ºC |
| 溶解度 | H2O: insoluble |
| 折射率 | 1.6910 (estimate) |
| 酸度系数 | pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain) |
| 存储条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 稳定性 | Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below. |
| 敏感性 | Light Sensitive & Hygroscopic |
| 外观 | powder |
| Merck | 14,5985 |
| BRN | 70669 |
| 物化性质 | 橙黄色结晶性粉末。熔点185-204℃。易溶于稀碱、酸或碱金属的碳酸盐溶液，微溶于稀盐酸，几乎不溶于水、乙醇、氯仿、**。 |
| 产品用途 | 抗肿瘤药，用于各种急性白血病、绒毛膜上皮细胞癌、恶性葡萄胎及牛皮癣症 |