| 中文名 | 艾氟康唑 |
| 英文名 | (R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol |
| 别名 | 艾菲康唑 艾氟康唑 伊非那康唑杂质 艾菲康唑及杂质 艾菲康唑及相关杂质 艾氟康唑(API) (2R,3R)-2-(2,4-二氟苯基)-3-(4-亚甲基哌啶基-1-基)-1-(1H-1,2,4-三唑-1-基)丁烷-2-醇 |
| 英文别名 | KP-103 KP103 Jublia KP 103 JUBLIA KP 103 Efinaconazole Efinaconazole(Jublia) KP 103 (pharmaceutical) (R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)- (alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol |
| CAS | 164650-44-6 |
| EINECS | 813-597-5 |
| 化学式 | C18H22F2N4O |
| 分子量 | 348.39 |
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 熔点 | 192-195°C |
| 沸点 | 512.2±60.0 °C(Predicted) |
| 溶解度 | Chloroform (Slightly), Methanol (Slightly) |
| 酸度系数 | 12.11±0.29(Predicted) |
| 存储条件 | -20°C |
| 外观 | powder |
| 颜色 | white to beige |
| 体内研究 | Topical Efinaconazole solution (0.25 to 1%) is dose-dependently effective in treating both dermatophytoses, for 10 guinea pigs with interdigital tinea pedis or tinea corporis is investigated. The follow up study performs on day-30 and day-9 posttreatment demonstrated that the relapse rates for 1% Efinaconazole-treated animals with tinea pedis and for those with tinea corporis are 20 and 30%, respectively. When a single dose of 1% Efinaconazole is applied to the back skin 48 hours before fungal inoculation, 9 of the 10 animals are protected from the dermatophytosis, suggesting that active Efinaconazole is retained in skin tissue for at least 48 hours after dosing. |